TMS and antidepressants both treat depression effectively, but they work differently, suit different people, and are not in competition with each other.
Antidepressants modulate the chemicals between your nerve cells – a daily intervention that depends on continued dosing. TMS stimulates the nerves themselves, building new connections over a course of treatment. These different mechanisms mean the two options suit different situations, and in some cases your doctor may recommend both at the same time.
This page helps you understand how each treatment works, what the evidence shows, how side effects compare, and – most importantly – which pathway may be the better fit for where you are right now.
TMS vs. Antidepressants at a Glance
The table below compares the two treatments across the factors that matter most to people making this decision.
| Antidepressants | TMS therapy | |
|---|---|---|
| Mechanism | Modulates the chemicals (primarily serotonin) between nerve cells – a daily, systemic intervention | Stimulates the nerves themselves using targeted magnetic pulses, building new connections in mood-related brain regions |
| Evidence | Many people benefit; response falls with each additional trial – approximately 40% at the first, 25% at the second, 16.8% at the third (STAR*D) | Neuralia cites an approximately 60–65% response rate as a conservative estimate; note that STAR*D tracked medication sequences in a treatment-resistant population – the same population Medicare covers TMS for |
| Side effects | Effects vary by medicine; may include sexual dysfunction, emotional blunting, appetite changes, or withdrawal symptoms on stopping | Potential side effects include temporary scalp tenderness, which affects about 1 in 10 patients, and the occasional mild headache; seizures are extremely rare |
| Time commitment | Daily dosing, supported by regular medical reviews | 35 sessions across four to seven weeks, three to five times per week |
| Medicare position | Pharmaceutical Benefits Scheme support varies by prescribed medicine | For eligible patients with Treatment-Resistant Depression, Neuralia offers a no-gap Medicare option – no out-of-pocket cost |
| Suitable pathway | Often considered early in depression care, especially when a person can follow a daily medicine routine | Often considered after trials of two or more antidepressants, or when a drug-sparing approach matches the person’s goals |
Both approaches can work together. A clinician may coordinate both when their combined effects suit the person’s needs.
How Antidepressants Work
Antidepressants belong to what clinicians sometimes call Psychiatry 2.0 – treatments that work by modulating the chemicals between nerve cells. The brain contains approximately 100 billion nerve cells, and antidepressants adjust the neurotransmitters (primarily serotonin) that pass between them. Their effects develop through continued daily dosing, with symptom improvement typically emerging over several weeks.
Medication classes and how they work
Selective serotonin reuptake inhibitors (SSRIs) reduce serotonin reuptake, leaving more serotonin available between neighbouring nerve cells. Serotonin and noradrenaline reuptake inhibitors (SNRIs) affect both messenger systems, extending their influence across related mood pathways. Your prescriber selects the most appropriate class after reviewing your symptoms, health history, and any previous medication responses.
Why antidepressants take time to work
Changes in chemical availability happen soon after dosing begins, but symptom improvement depends on slower adaptations across receptors and connected neural networks – which is why it can take several weeks to feel a difference.
Daily dosing maintains the prescribed exposure as the brain adjusts over several weeks. Regular reviews help the prescriber assess benefit and comfort before maintaining the dose or making a supervised adjustment.
Why response to antidepressants varies between people
Depression presents varied symptom patterns, and individual health history influences how you respond to prescribed medication. Metabolism affects how quickly your body processes a medicine and how long its effects remain active. You may benefit from the first prescription or find a better fit after trying a different class or dose. Side effects can guide later decisions. If you and your doctor decide to reduce or stop a medication, every taper should be doctor-supervised – stopping abruptly can cause withdrawal symptoms.
Where antidepressants fall short
Antidepressants have helped many people, and they remain an important part of depression care. But the STAR*D trial – the largest study of treatment-resistant depression ever conducted – showed that response rates fall significantly with each additional medication tried: approximately 40% at the first trial, 25% at the second, and 16.8% at the third.
For a significant proportion of people, medications either don’t work adequately or produce side effects – particularly sexual dysfunction and emotional blunting – that make continued treatment difficult.
This doesn’t mean medication should be avoided. It means TMS exists as an evidence-based option for people who haven’t found adequate relief.
How TMS Works Differently
TMS represents a different generation of treatment – what some clinicians describe as Psychiatry 3.0. Rather than adjusting the chemicals between nerve cells, TMS uses targeted magnetic energy and stimulates the nerve cells themselves. Each magnetic pulse creates a brief electrical current within selected areas of the prefrontal cortex – the brain region linked with mood regulation. Repeated sessions over a course of treatment encourage the brain to build new neural connections, a process called neuroplasticity.
How TMS delivers stimulation
A clinician places a magnetic coil against your scalp near the prefrontal cortex. The changing magnetic field passes through the skull and induces a small electrical current within the cortical tissue beneath the coil. Clinicians can use the stimulation pattern to increase or reduce activity, depending on the protocol and treatment target.
The mapping session
Your first appointment includes a mapping session, which gives the clinician a measurable way to personalise stimulation intensity before treatment begins. The clinician applies a pulse over the motor cortex until it produces visible movement in your thumb or fingers. This motor threshold is then used to calibrate your treatment intensity – ensuring stimulation is matched to your individual neurology.
How neuroplasticity produces lasting results
By activating the same targeted pathways tens of thousands of times across a course, TMS encourages the brain to strengthen and build new neural connections. Neuroplasticity describes the brain’s capacity to reorganise and grow more connections.
This structural change – rather than a chemical one – is why a single course of TMS can produce results that often last well beyond the treatment period, unlike daily medication that depends on continued dosing.
What a TMS course involves
You remain awake in a reclining chair as the coil delivers pulses during each scheduled session. Sessions at Neuralia last approximately 20 minutes, followed by an immediate return to normal daily activities – no anaesthesia, no recovery time, and no need to arrange transport.
An initial course involves 35 sessions, scheduled three to five times per week. The full course spans approximately four to seven weeks. Neuralia offers extended clinic hours – before and after standard business hours – to accommodate people who work full-time.
What the Evidence Shows
The STAR*D trial and Neuralia’s TMS response figure are not a direct head-to-head comparison – their populations and study contexts differ. Understanding both sets of figures clearly is more useful than treating them as opposing scores.
STAR*D tracked outcomes across successive medication steps, examining what happens when people with major depressive disorder try one antidepressant after another. Neuralia’s approximately 60–65% response figure reflects a population receiving TMS – typically after previous treatments. A response means a clinically meaningful reduction in measured depression symptoms; remission means symptoms fall below the clinical threshold entirely.
- First medication trial: Approximately 40% of STAR*D participants responded at the first treatment level.
- Second medication trial: Response fell to approximately 25% after the first medication failed.
- Third medication trial: Response fell further, to approximately 16.8%, after a second medication failed.
- TMS response: Neuralia cites an approximately 60–65% response rate as a conservative estimate.
- Population context: STAR*D examined sequenced medications in a treatment-resistant population – the same population Medicare covers TMS for.
- What this means for you: These figures support informed conversations with your doctor, but your individual care history and current symptoms guide the treatment decision that applies to you.
Side Effects Compared
Both treatments have known side effects – and both are manageable. The key difference is that antidepressant side effects are systemic (affecting the whole body through chemical circulation), while TMS side effects are localised and temporary. Neither should be overstated; many people tolerate both treatments well.
| Side-effect consideration | Antidepressants | TMS therapy |
|---|---|---|
| Common effects | Effects vary across medicine classes and may include nausea or changes in sleep | Scalp discomfort affects about 1 in 10 patients; an occasional mild headache may occur |
| Sexual and emotional effects | Sexual dysfunction or emotional blunting can occur – among the most commonly reported reasons people seek an alternative treatment. However, many people take antidepressants without experiencing these effects at all. | Targeted, localised stimulation means sexual and emotional blunting effects – typical of systemic medications – are outside the usual TMS profile |
| Appetite and weight | Appetite changes may contribute to weight gain, depending on the prescribed medicine and individual response | Not applicable – TMS targets cortical stimulation rather than circulating through the body |
| Stopping treatment | Rapid dose reduction can cause withdrawal symptoms; every taper should be doctor-supervised | Sessions conclude according to the planned course schedule, with follow-up care guided by the person’s response |
| Comfort management | A prescriber may adjust the dose or medicine if side effects affect daily comfort | The treating team can reposition the coil by a few millimetres to improve comfort; Panadol is usually effective for mild headaches. |
| Rare risk | Risks vary by medicine and individual health history | Seizures occur in approximately 1 in 50,000–60,000 sessions among patients without identified risk factors |
| Suitability screening | A prescriber reviews current medicines and relevant health conditions before recommending treatment | TMS is not suitable for people with epilepsy or a history of seizures or those with ferrous (magnetic) metal implants in the head or neck area. Standard dental fillings and non-ferrous implants are not contraindications. Every patient receives an individual assessment before treatment begins. |
Which Treatment is Right for You?
The most suitable pathway depends on your treatment history and current situation – not on a universal ranking. Your doctor is the right person to help you work through this decision, but the following framework gives you a starting point.
- If you are new to depression treatment: Your doctor will typically consider antidepressant medication as the first step, depending on your symptoms and medical history. This is the established clinical pathway, and medication helps many people significantly.
- If you have tried two or more antidepressants without adequate relief: TMS may offer another evidence-based pathway. Medicare covers TMS specifically for this situation – Treatment-Resistant Depression is defined as failure to respond to at least two antidepressant trials.
- If medication side effects are affecting your quality of life: A drug-sparing approach may suit your situation when systemic effects – particularly sexual dysfunction or emotional blunting – are influencing your daily comfort.
- If you want to combine both treatments: TMS and antidepressants may form part of the same treatment plan. A psychiatrist may continue your existing prescription during TMS treatment, allowing chemical modulation and neural stimulation to work alongside each other.
- If daily routine is a factor: You take medication at home on a daily schedule. TMS requires clinic attendance three to five times per week across four to seven weeks. Neuralia’s extended clinic hours are designed to accommodate people who work full-time.
Every medication decision – including stopping, reducing, or changing – is made with your doctor.
Does Medicare Cover TMS?
TMS was listed on the Medicare Benefits Schedule in November 2021, specifically for Treatment-Resistant Depression (TRD). This was a landmark moment for Australian mental health care – TMS previously cost approximately $8,000 out-of-pocket.
To be eligible for a Medicare-funded TMS course, you generally need to:
- Be aged 18 or over
- Have a diagnosis of a major depressive episode
- Have completed adequate trials of at least two different antidepressant classes, each at a therapeutic dose for at least three weeks
- Have not previously received rTMS treatment in a public or private setting
- Meet the remaining clinical and adherence criteria, including psychological therapy where clinically appropriate
An initial Medicare course covers up to 35 sessions.
In March 2023, Neuralia TMS became Australia’s first multi-site TMS-specific service to offer a no-gap Medicare option – meaning eligible patients pay nothing out of pocket. Australia now has among the highest levels of TMS access in the world.
The right starting point is an individual assessment. A clinician at Neuralia can review your depression history, previous medication responses, and treatment goals and confirm whether TMS is clinically appropriate and whether you meet Medicare eligibility criteria.
Book a free initial consultation here or call (08) 6230 3996 (WA) or (03) 9122 5246 (VIC). A clinical assessment at Neuralia will confirm whether you meet the eligibility criteria and explain the referral pathway that applies to your situation.
FAQs on TMS vs. Antidepressants
What are the most common TMS therapy side effects?
The most commonly reported side effects are temporary scalp discomfort (affecting about 1 in 10 patients) and occasional mild headache. The treating team can reposition the coil to relieve discomfort, and Panadol is usually effective for headaches.
Seizure is extremely rare, approximately 1 in 50,000–60,000 sessions in patients without risk factors. TMS is not suitable for people with epilepsy, a seizure history, or ferrous metal implants in the head or neck.
Does Medicare cover TMS for depression?
Yes, for Treatment-Resistant Depression (TRD). Medicare covers an initial course of up to 35 sessions for eligible adults who have not responded adequately to at least two antidepressant trials. Neuralia offers a no-gap option for eligible patients. A clinical assessment will confirm whether you qualify.
Can TMS and antidepressants be used together?
Yes. The two treatments work through different mechanisms, and a psychiatrist may continue an existing prescription during a TMS course. Combining approaches is an individual clinical decision made with your doctor.
Is medication the best treatment for ADHD?
Stimulant medication remains a first-line, evidence-based ADHD treatment, though the right choice depends on individual needs, age, and symptom profile. TMS protocols for ADHD are an emerging research area. Neuralia does not currently offer ADHD stimulation as an established service. Speak with your prescribing doctor.
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